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Topical glutathione Creams, lotions and glutathione-based peels that act at the application site

Guidance Document on Mammalian Reproductive Toxicity Testing and Assessment

Main methods Assessment included magnesium sulfate (560 mg/kg intraperitoneally)-induced muscle weakness, muscle and brain lesions, hypermagnesemia, hyperkalaemia, increased serum enzyme values assessed in rats during and at the end of a 30-min period and medication (given intraperitoneally/kg at 15 min before magnesium) [BPC 157 (10 g, 10 ng), l-NAME (5 mg), l-arginine (100 mg), alone and/or together]

Commenters supported CMS's efforts to strengthen the role of patient safety in the Overall Hospital Quality Star Rating and urged the agency to proceed thoughtfully, with continued interested party engagement and a focus on equitable, transparent implementation