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These factors result in DNA damage and mutations, genomic instability, inhibition of DNA repair, and enhanced cell survival 124,125,126 , thus priming biliary cells for carcinogenesis 1,80,123,127,128

For rats in the acupuncture group, bilateral Zusanli (ST 36) and Sanyinjiao (SP 6) were stimulated by manipulating the acupuncture needles intermittently for 20 min, once daily, and with 7 days being a treatment course

However, data are lacking regarding the impact of ascites on cardiac function assessed by contemporaneous echocardiographic markers

The timing and likelihood of success will depend on which option is taken, what decision is subject to challenge, and the facts of the particular case