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Front Neurol 15:1411143 Garca-Campos P, Bez-Matus X, Jara-Gutirrez C, Paz-Araos M, Astorga C, Cea LA, Rodrguez V, Bevilacqua JA, Caviedes P, Crdenas AM (2020) N-acetylcysteine reduces skeletal muscles oxidative stress and improves grip strength in dysferlin-deficient Bla/J mice

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Disclosures: Bradley Busebee: Nothing to Disclose, Kymberly Watt: Madrigal: Stock - publicly traded company, Viking: Stock - publicly traded company, Kara Dupuy-McCauley: Nothing to Disclose, Stephen Harvey: Nothing to Disclose, Hilary DuBrock: Nothing to Disclose 2145 ELEVATION OF CONJUGATED BILE ACIDS AND IL-6 IN CHRONIC LIVER DISEASES REGULATES MUSCLE TYPES AND INFLAMMATION Akiko Eguchi 1 Motoh Iwasa 1 Motoyuki Kohjima 2 Teruo Miyazaki 3 naoki yamashita 2 Mina Tempaku 1 Kiyora Izuoka 1 Yoshinao Kobayashi 1 Yoshiyuki Takei 1 Akira Honda 3 Hayato Nakagawa 1 Tadashi Ikegami 3 Makoto Nakamuta 2 , 1 Mie University, 2 NHO Kyushu Medical Center, 3 Tokyo Medical University Ibaraki Medical Background: The prevalence of sarcopenia in patients with chronic liver disease (CLD) is likely higher than in other diseases, with adverse effects on clinical outcomes such as falls, fractures, physical disability, and mortality

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