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In the early 1990s, researchers began focusing on the role the pineal gland plays in the aging process, specifically, its ability to modulate functions of the neuroendocrine and immune systems, which have been shown to decease with age

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GADD45 directly interacts with SIRT1 Although GADD45 overexpression increased SIRT1 protein levels, it did not affect SIRT1 mRNA expression as determined by qRT-PCR (Fig