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10.1016/s0753-3322(03)00043-x Biomed Pharmacother

The first step is a conversation

We then performed a gene set enrichment analysis (GSEA) to determine the association between the expression of ACTL6A and signaling pathways in the RNA array results, which indicated significant differences between ACTL6A-KD cells and control cells in multiple metabolism-related pathways, among which GSH metabolism ranked as one of the most highly correlated pathways (Fig

The converse is also true, as blocking TCA entry of either carbohydrates or fats decreases NADPH and GSH, makes the ER more oxidizing, and diminishes ER stressan effect that can be phenocopied by inhibiting GR (Gansemer et al., 2020)