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Emerging technologies such as organoids offer a powerful platform for simulating multiorgan interactions in vitro, enabling researchers to study dynamic cross-talk under controlled conditions, such as liverislet axis responses to metabolic stress, although challenges in replicating whole-body complexity remain

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Notably, elevated levels of 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], a subclass of eicosanoids, activate the intracellular cation channel transient receptor potential vanilloid one and mediate endothelial dysfunction in DM (Otto et al., 2020)

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