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Marcel Dekker, Inc, Basel, New York,RileyR

41 Slc3a2-dependent BCAA metabolism also has a key role in the physiological activities of Foxp3 + Treg cells, and either BCAA deprivation or SLC3A2 mutation can induce impaired activation of the mTORC1 pathway in Treg cells and inhibit the immunosuppressive function of Treg cells

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Based on the above research findings, future studies will aim to develop T cell-specific antibodies targeting the transferrin receptor to avoid potential off-target effects (as the transferrin receptor mediates iron uptake in many cell types)