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In particular, there have been many breakthroughs in the design of DON prodrugs, by modifying the carboxyl and amino groups of DON to obtain prodrugs that are not metabolized in plasma but decomposed in target cells, including acetyllysine substituted DON and JHU-083

It should be clearly stressed that the formation of nitrosating species in hydrophobic environments does not necessarily lead to increase nitrosation of thiols in that microdomain