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Still, researchers make it clear that "additional studies focusing on long-term supplementation and its longitudinal effect on the TMAO metabolism and cardiovascular system are needed." Most recently, a 2021 population study, including an average follow-up of 8 years, noted that elevated plasma levels of TMAO, as well as its precursor -- choline, predict incident risk for cardiovascular disease development independent of traditional risk factors

Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Others may see benefits over the next few days