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Loss of sex and age-driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice

High doses offer no added benefit and may cause gut upset

For example, myofascial pain syndrome (MPS) is a distinct clinical entity in which the development of discrete areas of exquisite pain (i.e., trigger points versus tender points) causes radiation of pain in stereotypic patterns