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Henry et al., 2006) and used for Wilson disease therapy in clinical trial (NCT00004339) by reducing Cu deposition in liver and brain (Kirk et al., 2024

Collectively, the findings indicates that enhanced mitochondrial fission coupled with diminished fusion represents a defining feature of CVDs and likely plays a central role in the pathogenesis of several cardiovascular complications including heart failure, diabetic cardiomyopathy, and atherosclerosis