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It exerts anti-inflammatory effects by inhibiting the gene expression of pro-inflammatory cytokines such as IL-1, IL-1, IL-6, and IL-12p35, downregulating the activity of inflammatory enzymes like iNOS and COX-2, and suppressing key factors in inflammation signaling pathways such as NF-B, FOXO3a, and SIRT1(Hara-Kudo et al., 2005

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Moreover, results show a significant overlap between polyphenolic compounds and Alzheimer's disease (AD) at the molecular level, with 49 genes (29.3%) associated with polyphenols and 110 genes (65.9%) linked to AD, including 8 common genes (4.8%) (Figure 4D)

CNS spectrums