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This mechanism is the foundation of its documented ability to stimulate keratinocyte, endothelial cell, and stem/progenitor cell migration to sites of tissue damage in pre-clinical models

18 Table 4 Time to Improvement of Abnormalities in Vitamin B12 Deficiency After Initiation of Treatment A 2005 Cochrane review involving 108 patients with vitamin B 12 deficiency found that high-dose oral replacement (1 mg to 2 mg per day) was as effective as parenteral administration for correcting anemia and neurologic symptoms

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Its early success led to widespread useand misusein lay herpetoculture