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Normal inflammation does not produce pus, does not worsen after the first 12 hours, and does not cause fever

Besides conventional drug discovery approaches, cost-effective ways to accelerate identification of novel antimalarial strategies have included (i) combination therapy, by joining two or more known drugs, (ii) covalent bitherapy, by conjugating different pharmacophores, (iii) repurposing of drugs with other therapeutic indications, and (v) rescuing of known antimalarial scaffolds