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High and chronic stress negatively aects physical health and promotes psychopathological symptoms (Jimnez-Ortiz et al., 2019)

A central regulator of this process is peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), which promotes mitochondrial biogenesis and reduces inflammatory signaling

In the same context, our study showed that Sert inhibits haemorrhagic transformation as detected by suppressed expression of CD163 in neurons, MMP-2,9 levels, ferric ion deposits and activity of HO-2 as compared to the cerebral I/R group

Then washed the cells twice with 500 l TE (10 mM TrisHCl, 1 mM EDTA, pH 8.0) and resuspended them in 250 l of TE