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doi: 10.1016/j.smim.2016.10.009 34 ONeillLAKishtonRJRathmellJ

In healthy adults, its activity declines with age, contributing to the progressive loss of synaptic density and cognitive flexibility that most people experience starting in their 40s and 50s

This was confirmed by AlphaFold predictions, suggesting how NS3h and NS5B could be recruited, through known cis-acting RNA elements, to the 3UTR, where a complex between NS3h, NS5B and the terminal stem-loop would be involved in priming () strand synthesis