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Evaluation of analgesic, anti-inflammatory, thrombolytic and hepatoprotective activities of roots of premna esculenta (Roxb)

Validation of a previously uncharacterized transsulfuration reaction with glutathione As in the reference transsulfuration reaction (R03923), cysteine is converted to serine by transferring the sulfur to tRNAs and producing thiolated tRNAs, which play essential functions in regulating cellular translational capacity and metabolic homeostasis 29

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Overactivation of AMPARs and KARs induces Na + overload, which leads to increased cellular permeability and results in cellular swelling and neuronal death