glutathione-related factors and oxidative stress in autism a review Frontiers The Role of Nutrition, Oxidative

A preliminary analysis of a dhar2 mutant reported that although DHA was somewhat increased compared to Col-0, GSSG levels were similar in the two lines (Yoshida et al., PRXIIF function had slight effects on root glutathione pools in control conditions, but little difference from wild-type was observed during stresses involving exposure to cadmium or to an inhibitor of the mitochondrial alternative oxidase (Finkemeier et al., gstu17 mutants that showed altered stress responses were reported to have increased root and shoot glutathione contents in unstressed conditions, although no data for glutathione redox state or glutathione contents during stress were presented (Chen et al., While loss-of-function studies are a more incisive approach to establishing the roles of specific genes, overexpression studies can also provide useful indications of the potential importance of a given enzyme

Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response

no subject in the trial surpassed the upper boundary of 110% of the prescribed number of prophylactic infusions

GSH, but not GSSG, reversed the effect of 2-AAPA, confirming the mechanism of toxicity as redox imbalance and the inability to recycle GSH from GSSG