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The amount of homocysteine in the blood is regulated by at least four vitamins: folate, vitamin B 6 , riboflavin, and vitamin B 12 (see Figure 1 )

While many stimulation-induced changes across the metabolic network persisted regardless of DPI treatment, this analysis highlighted that the upregulation of PPP intermediates is specifically dependent on NOX activity

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Serial monitoring of circulating cell-free mtDNA during treatment enables the detection of dynamic changes in mutation burden, providing real-time insights into evolving drug resistance and guiding timely adjustments to therapy regimens [505]