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In the phase 1/2 trial, alpelisib (a PI3K inhibitor) plus nab-paclitaxel was well tolerated and showed encouraging efficacy, especially in patients with metastatic PIK3CA -mutated HER2 breast cancer, despite that TNBC has lower efficacy than HR+/HER2 patients

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Ann Biomed Res Educ

Similarly, immune cells in psoriasis patients exhibit significant oxidative stress, leading to lipid peroxidation and the production of pro-inflammatory mediators (224, 225) (see Section 3.1)