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Our results are supported by a recent publication indicating that 0.5 mM NAC alone had no effect on cell death after LPS+nigericin treatment, but was sufficient to reverse the protective effect of another cysteine-reactive drug, disulfiram, on pyroptosis (43)

Nature 620 (7973), 374380

Both ROS production and scavenging are tightly regulated by specific signaling proteins within the cell ( 3 Types of ROS ROS have become integral by-products of aerobic life since the evolution of molecular O 2 in the atmosphere, primarily produced by oxygenic photosynthetic microorganisms