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In a state of vitamin B 12 deficiency, the cell responds by redirecting folate metabolic pathways to supply increasing amounts of methyltetrahydrofolate

While GH deficiency can cause hair problems, supplementing GH in normal individuals does not reliably improve hair growth

Repeated freeze-thaw cycles are generally avoided in laboratory settings, as they may contribute to peptide degradation

Individuals at risk of vitamin B12 deficiency include older adults, people with gastrointestinal disorders, those who have had gastrointestinal surgeries, individuals on a strict vegan diet, individuals who take metformin for blood sugar control, and people taking proton pump inhibitors for chronic heartburn