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Gounder and his colleagues published results from a large NCI-funded clinical trial showing that the drug sorafenib (Nexavar), a targeted therapy approved for the treatment of advanced kidney, liver, and thyroid cancer, halted the growth of desmoid tumors

In the study by Zhu and colleagues, they show that -catenin and Glioma-Associated Oncogene Homolog 1 (Gli1) have a prominent role in this signaling pathway during fibroblast migration [99]