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Effects may take time A few users did not notice immediate changes or are still waiting to see long-term results

Researchers choose between the formulations according to the biological pathways they wish to investigate

Patients were included in 2 groups: either effectiveness-based sequencing (EBS) if they started with infliximab or vedolizumab, or acceptability-based sequencing (ABS) if they received adalimumab or golimumab as first-line biologic