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Stephanou Electronic supplementary material Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

Introduction Aging is a substantial risk factor for the development of inflammatory conditions, such as osteoarthritis (OA) and, probably, other degenerative, and neoplastic diseases of the bone, such as Paget disease of the bone and osteosarcoma ( Insulin/IGF1R Signaling Pathway The insulin/IGF-1 signaling system (IIS) is the route that regulates not only the organism's metabolism, but also the growth, development, and longevity concerning the availability status of nutrients

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Composition: Coenzyme Q (300 mg) + L-Carnitine (50 mg) + Lycopene (5 mg) + L-Arginine (100 mg) + Selenium (0.04 mg) + Vitamin E (10 mg) + Zinc (17 mg) + Eicosa Pentanoic Acid (90 mg) + Docosahexaenoic Acid (60 mg) + Vitamin C (80 mg) What it does: Supports cellular energy production, helps maintain healthy heart function, and contributes antioxidant defence for overall vitality