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Likewise, the combination of HCQ and vorinostat in advanced solid tumors demonstrated manageable toxicity and indications of lasting responses, reinforcing the idea that blocking autophagy can enhance the effects of additional therapeutic agents

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After 90 days of topical melatonin 5% twice daily combined with sunscreen for 90 days, the MASI decreased by 31% compared with HQ 4% and sunscreen, which achieved a decrease of 37% [69]