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In further embodiments, non-hydrogen substituent includes fluoride (F)

Toxicol Appl Pharmacol 141:278287 Artigues A, Iriarte A, Martinez-Carrion M (2002) Binding to chaperones allows import of a purified mitochondrial precursor into mitochondria

Acronyms and abbreviations European union joint programme-neurodegenerative disease research glutathione disulfide glutathione peroxidase glutathione S-transferase glutathione synthetase glutathione reductase Parkinsons disease Alzheimers Disease neurodegenerative diseases reactive nitrogen species reactive oxygen species reduced glutathione oxidative stress 4-hydroxyl 2, 3-nenonal excitatory amino acid transporter C1 excitatory amino acid transporter -glutamylcysteine synthetase neurofibrillary tangles References 1

These effects can be categorized into three mechanisms