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In essence, there appears to be a link between the microbiome, gut inflammation, and the symptoms of ME/CFS (201)

This mechanism controls energy production, detoxification, and emotional balance

Finally, though carotid plaque assessment by ultrasound is a surrogate marker, it has now been validated as a meaningful predictor of cardiovascular events, with robust recommendations on the performance, standardization and clinical utility in the prediction of important atherosclerotic outcomes [19]