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Description

Tumor cells and myeloid cells in tumors express high levels of IDO1 [269,270,271,272,273,274,275], resulting in a low abundance of tryptophan [270] and high levels of kynurenine [270, 276]

Visualization of mitochondria by Mito-tracker Red CMX (red, middle) demonstrated co-localization with mitochondrial ROS (mROS) as detected by the 2,7-dichlorofluorescein diacetate (DCFH-DA) (green, left) fluorescence dye