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This approach should be associated with the environmental one, which consists of reducing exposure to toxic substances and choosing a healthy lifestyle: a balanced diet, regular and moderate physical activity, and continuous stress management

6 Future directions and challenges Despite significant advancements in understanding the role of ferroptosis in ARDS, several challenges remain in translating these findings into effective clinical strategies

Mechanistically, the principal ketone body 3-hydroxybutyrate (3HB) in a KD prevented the ICB-mediated upregulation of PD-L1 on myeloid cells while simultaneously promoting the expansion of CXCR3 + T cells