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Recommended dosage depends on level of insufficiency

In mouse models, loss of enzymes that modulate LDL oxidation increases atherosclerosis, and dietary antioxidants that reduce levels of oxLDL also inhibit atherosclerosis

The changes due to VLCAD were subtle in effect.[ref] Other studies in people with long-chain fatty acid oxidation disorders also show a modest increase in inflammatory cytokine levels, including during exercise challenges.[ref] Heart impacts: People with VLCADD are at a higher risk of heart problems, such as cardiomyopathy