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This demyelination process underlies subacute combined degeneration

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Accordingly, we found that in vitro activation and the costimulatory potential of GSH-deficient FoB was decreased compared to control cells upon 24h stimulation as indicated by lower expression of CD25, CD69, GL-7 and CD80/CD86 (Supplementary Fig

In order to help clear excess ROS and maintain the balance between ROS production and antioxidant defense system, endogenous antioxidant system exists in all cells including neurons 68 , but the activity of antioxidant defense system in the brain is low