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PMID: 8637402 Feeding-Behavior Research (MC3R/MC4R, Rodent Models) Central MC3R/MC4R-mediated food intake reduction in rats Beckman, Levine, and Billington ( Physiol Behav , 2009, PMID 19136019) and Trivedi and colleagues ( Brain Res , 2003, PMID 12834882) reported that central MC3R/MC4R agonism by Melanotan II decreased food intake in rodent models

Implications for therapeutic use The pharmacokinetic differences between SLU-PP-332 and 5-amino-1mq have significant implications for their therapeutic use: Dosing frequency: The rapid absorption and extensive distribution of SLU-PP-332 may allow for less frequent dosing compared to 5-amino-1mq

Carey and Pickarts ultrasound study found an average increase in collagen density of ~28% at 12 weeks, with top responders reaching 51%