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the limited amount of N-terminal cleavage seen in NpuDnaE intein, even at 50 mM DTT, may be due to the extremely rapid trans-splicing kinetics, given that the conversion of linear/branched intermediates to the trans-spliced product effectively competes with the nucleophilic attack by DTT

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Proc Natl Acad Sci U S A 92: 15851589

(2013) examined a high proportion of individuals with APOE4 among those with PDD and pure DLB, a type of DLB characterized by the presence of Lewy bodies without AD-like pathology, but they exhibited low amyloid-beta plaques