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Correlation between polyphenol content and anti-inflammatory activity of Verbascum phlomoides (mullein)

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For the rats administered either curcumin (25 or 50 mg/kg) or a combination of curcumin (25 mg/kg) with piperine (2.5 mg/kg) once daily for 21 consecutive days prior to 3-Nitropropionic acid administration (3-NP, a neurotoxin inducing symptoms of Huntingtons disease), it was found that both curcumin monotherapy and the curcumin-piperine combination demonstrated protective effects against 3-NP-induced motor deficit, biochemical alterations and neurochemical abnormalities