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Treatment with anti-interleukin 23 antibody ameliorates disease in lupus-prone mice

Melanin is responsible for skin pigment and is produced by melanocytes

Precision targeting of PTMs remains challenging: Although specific phosphorylation sites and ubiquitination patterns are known to regulate NRF2 stability, developing modifiers that selectively target these modifications without affecting other pathways is technically demanding

Instead of speeding up surface turnover, it signals fibroblasts in the deeper dermal layer to support collagen and elastin, and it carries copper for the enzymes that help cross-link new collagen