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Macrophages can promote angiogenesis (Lin et al., 2006)

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Month 2: More Consistent Fat Loss By month two, many patients reach a dose where effects are more noticeable: More consistent weekly weight loss Reduced snacking Improved eating control Better energy for some patients Typical cumulative loss by 2 months: 614 pounds Month 3: Visible Before and After Changes By month three, changes are often more noticeable: Clothing fitting looser Waist circumference reduction Improved metabolic labs Increased motivation Typical cumulative loss by 3 months: 818+ pounds 510% of starting body weight 6-Month and 12-Month Results From a medical perspective, semaglutide shows its greatest value over time