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Despite numerous studies during the past decades, cell-extrinsic and -intrinsic molecular mechanisms governing the dynamic metabolic changes in hepatocytes after partial hepatectomy (PH) still remain incompletely understood

Importantly, we demonstrated that the ectopic expression of PLK2, independent of its kinase activity, in several types of cancer cells promoted the caspase-3 processing, GSDME cleavage, DAMPs release, and cell death, albeit without IL-1 secretion