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doi: 10.1093/bioinformatics/btl485

Environmental exposure matters

Other studies in ApoE / mice demonstrated that TMAO repressed hepatic bile acid synthesis by inhibiting Cyp7a1 expression in the classical pathway of bile acid synthesis and that this inhibition might be mediated by activation of the nuclear receptor FXR and small heterodimer partner (SHP), thus accelerating the formation of aortic AS (Makishima et al., 1999