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The inconsistent results may be related with several reasons: mRNA stability, transcription factor activity, alternatively splicing, ribosome loading and translation efficiency, post-translational regulation, cell-cycle dependence, and environmental factors, etc

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Furthermore, studies in human atrial- and ventricular-programmed induced pluripotent stem cells or engineered heart tissues will allow for more long-term studies and higher throughput in elucidating LCAC pathophysiology and potential targeting strategies