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Idiopathic pulmonary fibrosis: IFIGENIA randomized placebo-controlled one-year studies with high dosages (1800 mg/day) of NAC added to azathioprine and prednisone therapy were done in 182 patients

This section provides a systematic integration of these concepts ( Figure 1 )

As evidenced in db/db and ob/ob mouse models (Thaiss et al., 2018), sustained hyperglycemia activates intestinal epithelial glucose transporter 2 (GLUT2) and downregulates the expression of zonula occludens-1 (ZO-1), increasing intestinal permeability