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Research by Jiang et al

Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria

In a study on cadmium chloride exposure, its impact on lung cancer (A549), hepatocellular carcinoma (HepG2), and normal lung cells (Wi38) was assessed, demonstrating the increased vulnerability of cancer cells [96]

Thus, researchers, clinicians, advocates and policy-makers should consider viewing the burden and management of spinal degeneration holistically as part of the OA disease continuum