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Fragment 176-191 (modified version of AOD9604) is a small piece of human growth hormone (hGH) that is sometimes referred to as the lipolytic fragment. Fragment 176-191 earned this latter name due to the fact that laboratory research has shown it to enhance fat burning, particularly in mice genetically engineered to produce large fat stores
To further validate the role of the erucamideTMEM19 axis at the in vivo level, we generated an adeno-associated virus encoding an shRNA (AAV2-shRNA) to knock down TMEM19 in rd10 mice
10.1098/rspb.2004.2821 132 PeckJ
Cardiovascular risk - Some peptide compounds, particularly growth hormone secretagogues, may affect insulin resistance or cardiovascular function in ways that are not adequately understood in humans
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