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Because it is essentially water without sufficient solute, direct intravenous administration can cause red blood cell lysis (hemolysis) due to its hypotonic nature

They should attend regular follow-up appointments and report any new or worsening neurological symptoms promptly

Biochemically, the cobalt center can take part in both two-electron and one-electron reductive processes to access the "reduced" (B 12r , +2 oxidation state) and "super-reduced" (B 12s , +1 oxidation state) forms

There is no published compatibility or stability data for the two peptides combined in a single solution, so keeping them separate is the conservative handling choice