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How to measure transcription-linked redox with rigor Methodologically, pair protein-centric readouts (redox proteomics of TF cysteines-Prx redox state) with compartment-targeted H 2 O 2 reporters in the nucleus or inner-nuclear membrane to capture flux and map footprints (3-nitrotyrosine, 8-oxoG) to link exposure with functional outcomes (Vaissier and Van Voorhis 2017