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Results Pathology Histopathological changes in smoke-exposed rats consisted of a reduction of tracheal mucosa epithelial layers at 75 and 200 mg TPM/m 3 (males and females) and 400 mg TPM/m 3 (one female), mucosal hyperplasia at 200 and 400 mg TPM/m 3 (males and females), and minimal to mild mucosal erosion in some males and females exposed to 75 and 200 mg TPM/m 3 (Table 1)

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