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The two non-nicotine medications are: bupropion SR (sustained release), a non-nicotine medication that is thought to decrease the urge to smoke by affecting the same chemical messengers in the brain that are affected by nicotine

However, all forms of tobacco come with a risk, and smokeless tobacco has a higher risk for a variety of dental issues

"It's hard to see how it could get any worse," Rohan Pike, a former Australian Federal Police detective and Border Force member, tells Reason

Nicotine acts on ionotropic nicotinic acetylcholine receptors (nAChRs), where ligand binding results in channel pore opening and cation influx across the membrane (89)