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Clinical findings often depend on the substance abused, the frequency of use, and the length of time since last used, and may include: Weight loss Constant fatigue Red eyes Little concern for hygiene Lab abnormalities Unexpected abnormalities in heart rate or blood pressure Depression, anxiety, or sleep problems Treatment for substance abuse or dependence: Specific treatment for substance abuse or dependence will be determined by your doctor based on: Your age, overall health, and health history Extent of the symptoms Extent of the dependence Type of substance abused Your tolerance for specific medicines, procedures, or therapies Expectations for the course of the condition Your opinion or preference A variety of treatment (or recovery) programs for substance abuse are available on an inpatient or outpatient basis

Peaky Blinders: Trailer for final season of BBC drama Peaky Blinders returned to BBC One on Sunday night, kicking off its blood-soaked sixth and final season