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F/up2) to acquire details about 1) their respiratory symptoms, 2) smoking status and conventional cigarette consumption per day (cig/day), 3) the number of severe COPD exacerbations in the prior 12 months, 4) post-bronchodilator lung function parameters (forced expiratory flow in 1 second [FEV 1 ]

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Moreover, free radicals originating from tobacco smoke are implicated in the etiology of many subtypes of oral cancer, as they induce a state of chronic inflammation that is considered a common feature of oral carcinogenesis ( see , next section) [1, 22, 23, 34]

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