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I then fill about one-quarter of the bowl and start right in smoking." Crosby wasn't picky when it came to pipes or if they had a filter, explaining, "If a pipe itself is of the correct size and weight for me, and the tobacco is good, then the type of filter, or no filter for that matter, makes little difference." While many pipe smokers have a designated pipe for each day of the week or rotate pipes throughout the day to allow them to rest between smokes, Crosby writes, "I have no set rule regarding the regularity of changing pipes or the number of pipes I smoke during the week.' Crosby estimated he switches pipes twice a week and periodically cleans his pipes with "some good cleaning fluid." Based on his own experiences, Crosby mentioned that excessive heat can cause a bowl to burn out and by maintaining a low, constant temperature, the pipe will taste better and each smoke will be enjoyable

Furthermore, it may be that women extract a greater quantity of carcinogens and other toxic agents from the same number of cigarettes than men, which again might explain why smoking confers a greater excess risk in women than in men.12 Lastly, female-specific factors or hormonal differences may explain the greater excess risk from smoking for lung cancer risk in women,34 ,35 yet evidence has been inconsistent and the possible mediating role of smoking remains unclear